Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence,
Treatment, and Outcomes
Beth A. Virnig, Todd M. Tuttle, Tatyana Shamliyan, and Robert L. Kane
Link to Journal
Scientific questions deserving further investigation include the relationship between mammography use and DCIS incidence and whether imaging technologies and treatment guidelines can be modified to focus on lesions that are most likely to become clinically problematic
(Ed).. There are dangers here in this approach, as DCIS is lumped together as a disease, despite data from the SLOANE Project in the UK showing significant differences in disease outcomes and likelihood of progression to invasive disease between the high grades and the low and intermediate grades of DCIS
Wednesday, 20 January 2010
Researchers Tackle Ductal Carcinoma in Situ and Its Many Unanswered Questions
Researchers Tackle Ductal Carcinoma in Situ and Its Many Unanswered
Questions
National Institutes of Health State-of-the-Science Conference Statement:
Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009
Carmen J. Allegra
Link to Journal
The diagnosis and management of DCIS is highly complex with many unanswered questions, including the fundamental natural history of untreated disease.
Because of the noninvasive nature of DCIS, coupled with its favorable prognosis, strong consideration should be given to elimination of the use of the anxiety-producing term "carcinoma" from the description of DCIS. The outcomes in women treated with available therapies are excellent.
Thus, the primary question for future research must focus on the accurate identification of patient subsets diagnosed with DCIS, including those persons who may be managed with less therapeutic intervention without sacrificing the excellent outcomes presently achieved.
Essential in this quest will be the development and validation of accurate risk stratification methods based on a comprehensive understanding of the clinical, pathological, and biological factors associated with DCIS
Questions
National Institutes of Health State-of-the-Science Conference Statement:
Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009
Carmen J. Allegra
Link to Journal
The diagnosis and management of DCIS is highly complex with many unanswered questions, including the fundamental natural history of untreated disease.
Because of the noninvasive nature of DCIS, coupled with its favorable prognosis, strong consideration should be given to elimination of the use of the anxiety-producing term "carcinoma" from the description of DCIS. The outcomes in women treated with available therapies are excellent.
Thus, the primary question for future research must focus on the accurate identification of patient subsets diagnosed with DCIS, including those persons who may be managed with less therapeutic intervention without sacrificing the excellent outcomes presently achieved.
Essential in this quest will be the development and validation of accurate risk stratification methods based on a comprehensive understanding of the clinical, pathological, and biological factors associated with DCIS
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