Lars Holmberg, Ole-Erik Iversen, Carl Magnus Rudenstam, Mats Hammar, Eero
Kumpulainen, Janusz Jaskiewicz, Jacek Jassem, Daria Dobaczewska, Hans E. Fjosne, Octavio Peralta, Rodrigo Arriagada, Marit Holmqvist, and Johanna Maenpa
On behalf of the HABITS Study Group
J. Natl. Cancer Inst. 2008 100: 475-482.
Link to the article
Hormone replacement therapy (HT) is known to increase the risk of breast cancer in healthy women, but its effect on breast cancer risk in breast cancer survivors is less clear. The randomized HABITS study, which compared HT for menopausal symptoms with best management without hormones among women with previously treated breast cancer, was stopped early due to suspicions of an increased risk of new breast cancer events following HT.
Conclusion: After extended follow-up, there was a clinically and statistically significant increased risk of a new breast cancer event in survivors who took HT.
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